PROJECTS
Structural landscape of the actin cytoskeleton
We are using cryo-EM to study the interfaces between diverse actin-binding proteins and actin filaments. Our studies support the concept tha...
Mechanical regulation of protein structure and function
We are developing technology for directly visualizing the effects of force on the conformation of actin filaments and their interactions wit...
Mechanisms of mechanical signal transduction
Mechanical cues impact a wide variety of cellular behaviors, including migration, growth, differentiation, and programmed cell death. We are...
TOOLS